RUNX3

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RUNX3와 위암 전이

Yu Chen et al.(2011)은 RUNX3 발현 손실이 위암 전이와 연관되어 있음을 시사하고 있다. 정확한 기작은 규명되지 않았다.

RUNX3이  TIMP-1을 상향 조절하여 MMP9 효소 활성을 억제하여 위암의 전이를 억제한다.

Yu Chen et al.Int J Cancer. 2011 Oct 1;129(7):1586-98. Runx3 suppresses gastric cancer metastasis through inactivation of MMP9 by upregulation of TIMP-1.

 

RUNX3 protein is believed to be involved in TGF-beta-mediated tumor suppressor pathway.

Tumor suppressive functions of RUNX3 in gastric carcinogenesis and colorectal carcinogenesis.

Physiological functions of RUNX3 in bone related tissues and diseases.

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