AKAP9

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A-kinase anchor protein 9 is an enzyme that in humans is encoded by the AKAP9 gene.

AKAP9 is an oncogene (papillary thyroid).

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in many isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3.[3]

InteractionsAKAP9 has been shown to interact with Calmodulin 1,[4] FNBP1,[5] CALM2,[4] Protein kinase N1,[6] TRIP10,[5] KvLQT1[7] and PRKAR2A.[8][6]

References

1.^ Lin JW, Wyszynski M, Madhavan R, Sealock R, Kim JU, Sheng M (Apr 1998). "Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1". J Neurosci 18 (6): 2017–27. PMID 9482789.
2.^ Westphal RS, Tavalin SJ, Lin JW, Alto NM, Fraser ID, Langeberg LK, Sheng M, Scott JD (Jul 1999). "Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex". Science 285 (5424): 93–6. doi:10.1126/science.285.5424.93. PMID 10390370.
3.^ a b "Entrez Gene: AKAP9 A kinase (PRKA) anchor protein (yotiao) 9". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10142.
4.^ a b Takahashi, Mikiko; Yamagiwa Akiko, Nishimura Tamako, Mukai Hideyuki, Ono Yoshitaka (Sep. 2002). "Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex". Mol. Biol. Cell (United States) 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. ISSN 1059-1524. PMC 124155. PMID 12221128.
5.^ a b Larocca, M Cecilia; Shanks Ryan A, Tian Lan, Nelson David L, Stewart Donn M, Goldenring James R (Jun. 2004). "AKAP350 interaction with cdc42 interacting protein 4 at the Golgi apparatus". Mol. Biol. Cell (United States) 15 (6): 2771–81. doi:10.1091/mbc.E03-10-0757. ISSN 1059-1524. PMC 420101. PMID 15047863.
6.^ a b Takahashi, M; Shibata H, Shimakawa M, Miyamoto M, Mukai H, Ono Y (Jun. 1999). "Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus". J. Biol. Chem. (UNITED STATES) 274 (24): 17267–74. doi:10.1074/jbc.274.24.17267. ISSN 0021-9258. PMID 10358086.
7.^ Marx, Steven O; Kurokawa Junko, Reiken Steven, Motoike Howard, D'Armiento Jeanine, Marks Andrew R, Kass Robert S (Jan. 2002). "Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel". Science (United States) 295 (5554): 496–9. doi:10.1126/science.1066843. PMID 11799244.
8.^ Alto, Neal M; Soderling Scott H, Hoshi Naoto, Langeberg Lorene K, Fayos Rosa, Jennings Patricia A, Scott John D (Apr. 2003). "Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (8): 4445–50. doi:10.1073/pnas.0330734100. ISSN 0027-8424. PMC 153575. PMID 12672969.
[edit] Further readingNagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
Schmidt PH, Dransfield DT, Claudio JO, et al. (1999). "AKAP350, a multiply spliced protein kinase A-anchoring protein associated with centrosomes.". J. Biol. Chem. 274 (5): 3055–66. doi:10.1074/jbc.274.5.3055. PMID 9915845.
Witczak O, Skålhegg BS, Keryer G, et al. (1999). "Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450.". EMBO J. 18 (7): 1858–68. doi:10.1093/emboj/18.7.1858. PMC 1171271. PMID 10202149. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171271.
Takahashi M, Shibata H, Shimakawa M, et al. (1999). "Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus.". J. Biol. Chem. 274 (24): 17267–74. doi:10.1074/jbc.274.24.17267. PMID 10358086.
Husi H, Ward MA, Choudhary JS, et al. (2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes.". Nat. Neurosci. 3 (7): 661–9. doi:10.1038/76615. PMID 10862698.
Takahashi M, Mukai H, Oishi K, et al. (2000). "Association of immature hypophosphorylated protein kinase cepsilon with an anchoring protein CG-NAP.". J. Biol. Chem. 275 (44): 34592–6. doi:10.1074/jbc.M005285200. PMID 10945988.
Marx SO, Kurokawa J, Reiken S, et al. (2002). "Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel.". Science 295 (5554): 496–9. doi:10.1126/science.1066843. PMID 11799244.
Steadman BT, Schmidt PH, Shanks RA, et al. (2002). "Transforming acidic coiled-coil-containing protein 4 interacts with centrosomal AKAP350 and the mitotic spindle apparatus.". J. Biol. Chem. 277 (33): 30165–76. doi:10.1074/jbc.M201914200. PMID 12015314.
Bray JD, Chennathukuzhi VM, Hecht NB (2002). "Identification and characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X.". Genomics 79 (6): 799–808. doi:10.1006/geno.2002.6779. PMID 12036294.
Shanks RA, Larocca MC, Berryman M, et al. (2002). "AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member.". J. Biol. Chem. 277 (43): 40973–80. doi:10.1074/jbc.M112277200. PMID 12163479.
Takahashi M, Yamagiwa A, Nishimura T, et al. (2003). "Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex.". Mol. Biol. Cell 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. PMC 124155. PMID 12221128. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=124155.
Sillibourne JE, Milne DM, Takahashi M, et al. (2002). "Centrosomal anchoring of the protein kinase CK1delta mediated by attachment to the large, coiled-coil scaffolding protein CG-NAP/AKAP450.". J. Mol. Biol. 322 (4): 785–97. doi:10.1016/S0022-2836(02)00857-4. PMID 12270714.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2882961.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Tu H, Tang TS, Wang Z, Bezprozvanny I (2004). "Association of type 1 inositol 1,4,5-trisphosphate receptor with AKAP9 (Yotiao) and protein kinase A.". J. Biol. Chem. 279 (18): 19375–82. doi:10.1074/jbc.M313476200. PMID 14982933.

 

 

 

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